Molecular Targeting of Human Papillomavirus oncogene expression using RNA interference Technology

tissue is accomplished by removal of keratinocytes harboring HPV. These are the conventional approaches for treatment of cervical cancer. Prophylactic vaccines are available and should be administered prior to viral exposure. Initiatives for vaccination have been undertaken by the governments and also non-governmental agencies. Attempts are being made to develop therapeutic vaccines that would treat prevailing HPV infection. Use of immunomodulators like interferon and imiquimod induce cytokine production to increase host immune response against HPV infection [5]. Many antioxidants and poly herbal formulations are also in use. Molecular targeting of HPV gene expression using RNA interference technology includes use of antisense oligonucleotides, ribozymes, short interfering RNAs (siRNA), short hairpin RNA (shRNA) etc. The present review is a criMolecular Targeting of Human Papillomavirus oncogene expression using RNA interference Technology Sarmistha Sen Raychaudhuri 1,* and Sreejata Raychaudhuri 2,†